JAK-STAT pathway: hacking protein regulation

So the JAK-STAT pathway, as with all pathways, have different functional effects. It is associated with cancer, immunodeficiency, growth retardation and many more.

different ligands induce the phosphorylation of different STAT residues. This increases provides a regulatory mechanism on the downstream signals. It is fascinating to see the different ways in which cells regulates proteins.

It would be interesting to utilise the cells method in controlling and understanding cellular function. This can be extrapolated to obtain therapeutic methods for the diseases associated with the JAK-STAT pathway or it can be used to counter bacterial infections.

I would like to know the differences between the phenotype and genotype between JAK-STAT caused diseases and those diseases with other causes.

Review: http://www.annualreviews.org/doi/full/10.1146/annurev-med-051113-024537

Protein structure of the JAK-STAT receptor. Image obtained from http://www.niams.nih.gov/Research/JAK-STAT_Meeting/