Tumour necrosis factor is a ligand the binds to the TNF receptors and activates downstream signalling pathways.
An interesting characteristic about the TNF signalling pathway is that they activate inflammatory-genes and it also induces apoptosis.
This might be a potential therapeutic target for cancer. By directing the gene or protein to specific tumour cells. It will be more specific than chemotherapy and more effective. The transmission method could be through retrovirus or a mechanism that pathogens utilise to enter the cell.
Function of TNF. Image obtained from http://www.sciencedirect.com/science/article/pii/S0165614710002105 |
review - http://www.nature.com/cdd/journal/v10/n1/full/4401189a.html
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